References:
1. Estrogen receptor expression on lymphatic vessel endothelial cells: Studies have demonstrated that lymphatic endothelial cells express functional estrogen receptors, and estrogen signaling influences lymphatic vessel permeability, contractility, and fluid transport.
2. Progesterone and fluid balance: Progesterone acts as a natural mineralocorticoid antagonist, promoting sodium and water excretion. Declining progesterone during perimenopause reduces this diuretic effect, contributing to fluid retention.
3. Collagen loss during menopause: Research indicates women lose approximately 30% of dermal collagen within the first five years of menopause, affecting structural support for lymphatic vessel anchoring filaments.
4. Inflammation and lymphatic dysfunction: Chronic low-grade inflammation associated with estrogen decline impairs lymphatic pumping capacity and increases vessel permeability, creating a self-perpetuating cycle of fluid stagnation and tissue inflammation.
5. Astragalus polysaccharides and lymphatic function: Studies have shown Astragalus membranaceus supports lymphatic vessel integrity and reduces capillary permeability through polysaccharide-mediated mechanisms.
6. Dandelion as a natural aquaretic: Research published in the Journal of Alternative and Complementary Medicine demonstrated dandelion leaf extract increases urinary frequency and volume, acting as a potassium-sparing diuretic.
7. Horsetail and bioavailable silica: Horsetail (Equisetum arvense) is a rich source of bioavailable silicon, which plays a role in collagen synthesis and connective tissue maintenance.
Nuvora supports the body's natural lymphatic drainage system and normal fluid balance. These statements haven't been evaluated by the Food and Drug Administration. This product isn't intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.